Porphyromonas gingivalis lipopolysaccharideÀÇ Àü½ÅÀû Åõ¿©¿¡ ÀÇÇÑ »ýÁã ³ú¿¡¼ ¿°Áõ À¯¹ß
Systemic injection of Porphyromonas gingivalis lipopolysaccharide induces inflammation in the mouse brain
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Á¤º¸Çö ( Jung Bo-Hyun ) - Gangneung-Wonju National University College of Dentistry Department of Anatomy
ÀÌÈñ¼ö ( Lee Hee-Su ) - Gangneung-Wonju National University College of Dentistry Department of Anatomy
À¯±â¿¬ ( Yoo Ki-Yeon ) - Gangneung-Wonju National University College of Dentistry Department of Anatomy
KMID : 0355820200410010055
Abstract
Ä¡ÁÖÁúȯÀ» ÀÏÀ¸Å°´Â ¼¼±ÕÀÎ Porphyromonas gingivalis ÀÇ lipopolysaccharide (PG-LPS)°¡ ³úÀÇ Ç÷¾×³úÀ庮(blood-brain-barrier)À» Åë°ú ÇÒ °¡´É¼ºÀÌ Á¦±âµÇ¾úÁö¸¸, ³úÀÇ ½Å°æ ¿°Áõ À¯¹ß°ú °ü·ÃµÈ Á÷Á¢ÀûÀÎ ¿¬°ü¼ºÀº ¸íÈ®ÇÏ°Ô ¾Ë·ÁÁ® ÀÖÁö ¾Ê´Ù. µû¶ó¼ º» ¿¬±¸¿¡¼ PG-LPS°¡ ³ú¿¡¼ ¿°Áõ°ú °ü·ÃµÇ¾î ¾î¶² ¿µÇâÀ» ¹ÌÄ¡´ÂÁö È®ÀÎÇÏ°íÀÚ ÇÏ¿´´Ù. º» ¿¬±¸¿¡¼´Â PG-LPS Åõ¿© ÈÄ 12 ½Ã°£°ú 24 ½Ã°£ ÈÄ¿¡ ¸é¿ªÁ¶Á÷ÈÇÐ ¿°»öÀ»ÅëÇØ ³ú Á¶Á÷ÀÇ º¯È¸¦ È®ÀÎ ÇÏ¿´´Ù. ¸é¿ªÁ¶Á÷ÈÇÐ ¿°»ö °á°ú, PG-LPS¸¦ Åõ¿© ÇÑ ¸¶¿ì½ºÀÇ ³ú¿¡¼ ¿°Áõ°ü·Ã ÀÎÀÚµéÀÌ ¹ßÇöµÇ´Â °ÍÀÌ °üÂûµÇ¾ú´Ù. ÀÌ¿Í °°Àº °á°ú´Â ±¸° ³» Ä¡ÁÖÁúȯÀ» À¯¹ßÇÏ´Â PG-LPS´Â ³ú¿¡¼½Å°æ¿°Áõ À¯¹ß°ú ¹ÐÁ¢ÇÑ ¿¬°üÀÌ ÀÖÀ½À» ½Ã»çÇÑ´Ù.
Porphyromonas gingivalis is a Gram-negative bacterium that causes periodontal disease in the oral cavity. The possibility that P. gingivalis lipopolysaccharide (PG-LPS) can pass through the blood?brain barrier has been restored; however, it is not known whether it leads to neuroinflammation in the brain. Therefore, in this study, we tried to determine if PG-LPS affects the brain. In this study, inflammatory changes in brain tissues were confirmed through immunohistochemistry 12 h and 24 h after PG-LPS administration. In result, inflammation and cytokine expression were observed in the brain of PG-LPS-administered mice. These results suggest that P. gingivalis can influence inflammation in the brain.
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Porphyromonas gingivalis; ÁöÁú´Ù´çÁú; ³ú; ¿°Áõ; »çÀÌÅäÄ«ÀÎ
Porphyromonas gingivalis; Lipopolysaccharide; Brain; Inflammation; Cytokine
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